Lidocaine and tissue penetration

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The increase in temperature causes the lipids in the stratum corneum to be more fluid, and therefore more permeable. Vasoconstrictors penetrate poorly the stratum corneum, so their efficacy in topical preparations is questionable. Examples are certain low molecular weight alcohols and ethers. Department of Pharmacy, The University of Queensland, Australia. There are considerable obstacles to overcome to achieve this, and to understand them it is necessary to consider the structure of the skin and the routes of penetration through it. These mixtures have a lower melting point that either component by itself, and as a result, the combination has better skin penetration than its parts alone.
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Lidocaine and Epinephrine

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Lidocaine topical Uses, Side Effects & Warnings - NCDF.INFO

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Lidocaine topical

Lidocaine can cause cardiac depression eg, bradycardia, hypotension ; patients with hypovolemia may be at increased risk. Tolerance to elevated blood levels varies with the status of the patient. J Chromatogr-Biomed Appl Applying this method to our data and using a MIC 90 of 0.
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